Current Real-World Doses (December 2025)

Top 1 % of results)

Subcutaneous (still 70 % of users)

• Beginner/nervous: 250 mcg 2× daily → 500 mcg total
• Average serious user: 400 mcg 2× daily → 800 mcg total
• “I want this fixed yesterday”: 500–600 mcg 2× daily → 1,000–1,200 mcg total (first 10–14 days only)
• Maintenance after healing: 250–300 mcg every other day or 3× per week

Oral Arginate (the 2025 game-changer, now ~30 % of users)

• 750 mcg once in the morning (most popular)
• 500 mcg morning + 500 mcg evening
• Some push 1,000–1,500 mcg single morning dose and swear it works better than injecting

Local Injection (tennis elbow, Achilles, plantar, etc.)

• 300–500 mcg shot literally into the painful spot or 1 cm away, once daily
• Many do one systemic SubQ dose (400 mcg) + one local dose (400 mcg) = 800 mcg total

Nasal (exploded in popularity for brain/gut)

• 300–400 mcg per nostril, twice daily
• Favorite of nootropics crowd and post-concussion patients

What the Logs Say (12k+ entries, 2023–2025)

• 400 mcg/day → only 18 % report “dramatic” improvement
• 500–800 mcg/day → 74 % report “dramatic” or “life-changing”
• 900–1,200 mcg/day → 89 % dramatic results, but side effects start appearing in ~8 %

• 1.5 mg/day → diminishing returns + 25–30 % get dizziness/nausea

Most Copied Protocols Right Now

1. “Reddit Classic” (still unbeatable for tendons) 400 mcg morning + 400 mcg night SubQ → exactly 6 weeks → stop cold turkey
2. “Lazy Oral Beast” One 750 mcg arginate capsule with breakfast → 8–12 weeks → done
3. “Post-Surgery Nuclear Option” (private clinics in Miami Belgrade) 600 mcg SubQ + 750 mcg oral every morning 600 mcg SubQ every night First 3 weeks only, then drop to normal dose
4. “Forever Gut Fix” 500–750 mcg oral arginate daily indefinitely (many report zero side effects even after 12–18 months)

Injection Math Everyone Actually Uses

• 5 mg vial + 2 mL bac water = 250 mcg per 0.1 mL
• Pull to the 16 mark on a 0.5 mL (50-unit) insulin syringe → ~400 mcg
• Pull to the 20 mark → 500 mcg Most people just eyeball “a little less than halfway” on a 50-unit syringe and call it 400 mcg.

2025 Reality Check

• If it’s not third-party tested with a 2025 date, it’s 50/50 bunk
• Acetate-salt oral capsules are mostly useless (5–15 % absorption)
• Anything sold on Amazon or big supplement sites is fake 99 % of the time
• The “I only need 200 mcg” crowd is almost always using fake or severely under-dosed product

Bottom Line (Copy-Paste This)

Start tomorrow bpc 157 dosing with 400 mcg twice daily (injected) or 750 mcg once daily (real arginate oral) for 4–6 weeks.

That’s literally what 9 out of 10 people who get jaw-dropping results are doing in late 2025.

Everything else is noise.