How to Play the Gas Grenade Pathfinder

The Gas Grenade Pathfinder has one of the easiest gameplay loops among poison builds. Here's how it works:

For general mapping:

1. Toss Gas Grenades into enemy groups.
2. Let Contagious Contamination automatically spread poison.
3. Move quickly to the next pack using flasks and movement skills.

For bosses and tanky elites:

Cast Despair to reduce chaos resistance.
Activate Toxic Domain for a single-target DPS boost.
Stack multiple Gas Grenades under the target for maximum poison layers.
Maintain Withering Presence to keep Wither stacks active and increase damage intake.

This method ensures strong consistency between fast mapping and heavy single-target encounters, letting you seamlessly handle both playstyles.

Best Skill Gem Setup for Gas Grenade Pathfinder

The Gas Grenade Pathfinder requires a strong five-link setup to Path of Exile 2 Currency reach its full potential. Below is the recommended configuration:

Gas Grenade: Arakali's Lust - Deadly Poison II - Elemental Armament II - Persistent Ground III - Encroaching Ground
(Swap Encroaching Ground for Elemental Focus against bosses.)
Ghost Dance: Compressed Duration II
Wind Dancer: Blind II - Maim - Magnified Area II
Despair: Heightened Curse - Prolonged Duration II - Efficiency II
Withering Presence: Prolonged Duration II - Clarity I
Toxic Domain: Escalating Poison - Deadly Poison II - Long Fuse II

Leveling Tip: Use Gas Grenade (Bursting Plague, Corrosion) with Contagion (Unleash) for smooth early progression. Against bosses, keep Explosive Grenade ready to detonate for buy POE2 Currency high burst damage while layering poison clouds.